M-Body is a class of molecules purposely designed to engage more than one signaling pathways. These molecules are generally composed of a core antibody and a biologically functional motif. By the modular structure design, M-Bodies are stable and long-acting, easy for manufacturing and purification. In addition, M-Bodies have demonstrated synergies/additive activities of the targeted two pathways on animal models, which in turn could improve the efficacy, lower toxicity and possibly expand indications of M-Bodies than single antibody. M-Bodies for diabetes, NASH, obesity, PAH, heart failure and solid tumors are in various stages of discovery and preclinical development.