BIBODY PLATFORM

 

Bibody Platform

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Bibody is a class of molecules purposely designed to engage more than one signaling pathways. These molecules are generally composed of a core antibody and a biologically functional motif. By the modular structure design, Bibodies are stable and long-acting, easy for manufacturing and purification. In addition, Bibodies have demonstrated synergies/additive activities of the targeted two pathways on animal models; which in turn could improve the efficacy, lower toxicity and possibly expand indications of Bibodies than single antibody. Bibody is a class of molecules purposely designed to engage more than one signaling pathways. These molecules are generally composed of a core antibody and a biologically functional motif. By the modular structure design, Bibodies are stable and long-acting, easy for manufacturing and purification. In addition, Bibodies have demonstrated synergies/additive activities of the targeted two pathways on animal models; which in turn could improve the efficacy, lower toxicity and possibly expand indications of Bibodies than single antibody. Bibodies for diabetes, NASH, obesity, PAH, heart failure and solid tumors are in various stages of discovery and preclinical development.